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Last Updated 5/20/2016 5:56 AM
HAMLET Core
Director(s): Director: Shunqiang Li, PhD
Contact: Shunqiang Li, PhD
Phone: 314-747-9311
Email: sqli@DOM.wustl.edu
Web:
Campus: Medical Campus Campus Box: 8069
School/Unit: Medicine
Academic Department: Internal Medicine
*Please contact this Core directly for physical location
Core Location
Building Name: Southwest Tower
Room Number: 724
Core Summary
Human and Mouse Linked Evaluation of Tumors
Access
Service available to:
All entities, including for-profit organizations

Priority service for:
No distinctions

Additional Information:
Affiliation

  • Department of Internal Medicine
Core Details

The vision of the HAMLET Core is to promote understanding of the biology and genetics of human breast cancer and to provide better preclinical models to validate new treatment and imaging approaches. These aims are achieved by providing investigators tumor lines which display genomic characteristics that are closely related to the human tumor from which they originated.

The mouse is an easily manageable system which avoids most of the problems and artifacts of attempted in-vitro cultures. Washington University Human in Mouse (WHIM) tumor lines have been propagated to at least three serial passages and have been characterized by gene expression, aCGH and in some cases complete whole genome sequencing.

 

Services

  • Training in procedures;Archived WHIM lines ;Tumor lysates from mice ;Nucleic Acid isolated from Human Tumor Lines (DNA, RNA) ;Paraffin-embedded tissue sections of WHIM tumors ;Preclinical experiment consultation
Equipment

  • Please contact core.
Pricing - subject to verification from the Core Facility.
Please contact core.

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