Animal Care and UseAward ManagementConflicts of InterestContracts and SubawardsControlled SubstancesEnvironmental Health and SafetyExport ControlHIPAAHuman Stem Cell ResearchHuman Subjects Research

NIH – SF424 (R&R) Application Form Instructions

Published August 19, 2021

The National Institutes of Health (NIH) updated their SF424 (R&R) Application Forms Instructions to Forms G.

NIH’s Forms-F application package is being replaced by the new FORMS-G application package, effective for deadlines on or after January 25, 2022. Accordingly, we will be working with our Research Management System (RMS) vendor to update the forms for System to System (S2S) proposal submissions. A follow-up announcement will be sent after RMS is updated.

Below is a list of details.

  • FORMS-G are required for due dates on or after January 25, 2022.
  • FORMS-E are required for due dates on or before January 24, 2022.
  • For a transition period, both FORMS-F and FORMS-G application packages will be active. Applicants must choose the appropriate application package for their due date when presented with both FORMS-F and FORMS-G application packages on the same FOA.
    • This will be the case for using RMS/S2S, ASSIST and Workspace.
If your intended due date is…You must use…
On or before January 24, 2022, including:

  • Applications submitted for due dates on or before January 24, 2022

  • Applications submitted under NIH Late Policy 2-week window of consideration for intended due dates on or before January 24, 2022

FORMS-F application package
On or after January 25, 2022, including:

  • Applications submitted for due dates on or after January 25, 2022

  • All application types (New, Resubmission, Renewal, Revision)
    Applications submitted early for intended due dates on or after January 25, 2022
FORMS-G application package
  • The following application forms include substantive changes (i.e. new/deleted/modified fields).
    • SF424 R&R
    • R&R Senior/Key Person Profile (Expanded)
    • R&R Budget and Associated Subaward Budget Attachment(s) Form
    • Project/Performance Site Location(s)
    • PHS 398 Training Budget and Associated Subaward Budget Attachment(s) Form
    • PHS Additional Indirect Costs
    • PHS Fellowship Supplemental Form
    • PHS Human Subjects and Clinical Trials Information
    • SBIR/STTR Information
  • Key changes:
    • As part of the federal-wide transition from the DUN and Bradstreet (D&B) Data Universal Numbering System (DUNS) number to the new government-owned Unique Entity Identifier (UEI), applicants will be required to have a UEI to apply for federal grants or cooperative agreements. The System for Award Management (SAM) will become the central repository for the new UEI that will be incorporated into an institution’s SAM registration. Although agencies are not required to fully transition until April 2022, NIH, AHRQ, and FDA will transition for due dates on or after January 25, 2022, to align with standard application and review cycles. See NOT-OD-21-170 for more information.
      • WashU’s UEI is L6NFUM28LQM5.
    • NIH will require the use of the updated Biographical Sketch and Other Support format pages for submissions on or after January 25, 2022. See NOT-OD-21-073, NOT-OD-21-110, and NOT-OD-21-122 for more information.
    • Targeting due dates on or after January 25, 2022, all Senior/Key personnel listed on the R&R Senior/Key Person Profile (Expanded) form will be required to have an eRA Commons username (Commons ID). Extension of the existing eRA Commons ID requirement to include all senior/key personnel will facilitate better data collection for individuals contributing to federally funded research as well as assist in disambiguating data on applications and facilitating the identification of conflicts of interest in peer review. See NOT-OD-21-109 for more information.
  • See High-level Summary of Form Changes in FORMS-G Application Packages for a full list of form changes.
  • New funding opportunity announcements (FOAs) will be posted with FORMS-G application packages beginning October 25, 2021.
  • New FOAs posted before October 25, 2021, with initial due dates on or after January 25, 2022, will be posted without application forms until updated forms are available. Application packages will be added to these FOAs by November 25, 2021.
  • All active Parent and IC-issued FOAs with due dates on or after January 25, 2022, will be updated to add FORMS-G application packages between October 25, 2021, and November 25, 2021.
  • Application guides for FORMS-G application packages will be posted to the How to Apply – Application Guide page no later than October 25, 2021.

Please share this information with all faculty and staff who may need this information.

If you have any questions, please contact the Office of Sponsored Research Services.