Our mission is to support the advancement of stroke and cerebrovascular clinical research, with the ultimate goal of improving the care of our patients affected by stroke and cerebrovascular disease.
The Stroke Patient Access Core (SPAC) provides investigators with a centralized infrastructure for all aspects of stroke clinical research. These include research feasibility analysis, regulatory responsibilities, recruitment, consenting, randomization, enrollment, follow-up, retention, and study closure.
Our Goal: Investigate the most effective and safe ways to save more brain and improve patient outcomes after suffering a stroke.
Video: St. Louis Mock Stroke Drill (https://youtu.be/68gUAcQUlXA)
- Mark VCID: https://markvcid.partners.org/
- Goal: discover potential biomarkers involved in small vessel diseases of the brain that impact cognitive impairment and the development of dementia. This will allow for a better understanding of and ways to treat these impairments in the future.
- StrokeNet: https://nihstrokenet.org/
- Goal: NIH StrokeNet is a network consisting of 27 regional centers across the United States and overseas relations that conducts small and large clinical research studies and trials to create advances in future stroke treatment, prevention, recovery, and rehabilitation.
- RVCL: https://rvcl-dev-research-washu.pantheonsite.io/
- Goal: to create awareness and improve patient care through clinical studies and drug trials for the newly discovered disease known as retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S).
- WUSTL Stroke: https://stroke.wustl.edu/
- ECRC: https://emergencymedicine.wustl.edu/research/ecrc/
- Our core closely collaborates with Emergency Care Research Core (ECRC) by enrolling patients in hyperacute research trials directly in the emergency department.
Service available to All entities, including for-profit organizations.
Priority service for All entities, including for-profit organizations.
- Research Feasibility Analysis: The SPAC team can provide analysis and evaluation through protocol review to determine the recruitment strategy for the individual study to optimize patient enrollment. The feasibility study will also provide information that may project study enrollment.
- Regulatory: Preparation of IRB submissions and interaction with the Human Research Studies Committee; interaction and communication with study sponsor.
- Recruitment: The screening process includes screening of daily acute ED stroke pages, all neurology inpatients, and stroke clinic outpatients. Most screens occur daily in real-time or at multiple time-points. We will approach all suitable candidates that meet criteria for the proposed study.
- Consent: The study's consent may be presented to the patient, family, or legally authorized representatives. The patient, family or legally authorized representatives should understand the purpose, procedures, and the potential risks and benefits of the study through the consent process. The patient or the legally authorized representative may be consented. The consent process will be documented according to the federal guidelines (45 CFR 46.116).
- Randomization: After completion and documentation of the consent process, we will randomize the patient according to the specific protocol requirements.
- Enrollment: Patients may be enrolled per the specific protocol guidelines (Follow-up: Visits will be scheduled according to the individual protocol schedule of events provided in the protocol.)
- Retention: Initial patient interview will include at least two alternate phone numbers for family or significant others. Phone calls may be made to retain the patient and confirm follow-up visits.
- Study Closure: Complete necessary patient final visits and end of study documents.
- Data recording and data entry: We collect and track information, create source documents, and work with the sponsor to streamline data recording and data entry.
- -80 freezer
Please contact this core directly for pricing information.
Center for Clinical Imaging Research (CCIR)
Institute of Clinical and Translational Sciences (ICTS)