Human and Mouse Linked Evaluation of Tumors

Core Description

The vision of the HAMLET Core is to promote understanding of the biology and genetics of human breast cancer and to provide better preclinical models to validate new treatment and imaging approaches. These aims are achieved by providing investigators tumor lines which display genomic characteristics that are closely related to the human tumor from which they originated.

The mouse is an easily manageable system which avoids most of the problems and artifacts of attempted in-vitro cultures. Washington University Human in Mouse (WHIM) tumor lines have been propagated to at least three serial passages and have been characterized by gene expression, aCGH and in some cases complete whole genome sequencing.

Access

Service available to All entities, including for-profit organizations.

Priority service for No distinctions.

Services

  • Training in procedures
  • Archived WHIM lines
  • Tumor lysates from mice
  • Nucleic Acid isolated from Human Tumor Lines (DNA, RNA)
  • Paraffin-embedded tissue sections of WHIM tumors
  • Preclinical experiment consultation

Equipment

  • Please contact core.

Pricing

Please contact this core directly for pricing information.


AFFILIATIONS
Department of Internal Medicine