Mallinckrodt Institute of Radiology operates a PET nuclear pharmacy and cyclotron facility for the routine production of PET radiopharmaceuticals and radiolabeled precursors used in research studies.
a) routine production of PET radiopharmaceuticals for clinical and clinical research use and production of Cu-64, Zr-89, Y-86, Br-76 and Br-77 for research use and distribution across the United States and Canada and
The cyclotron facility has a 19 MeV TR-19/9 variable energy Advanced Cyclotron Systems Inc. (ACSI) cyclotron, 11 MeV Siemens RDS Eclipse and 16 MeV Japan Steel Works JSW168. The GMP facility is used for the production of all human-use PET drugs which are produced under FDA’s Code of Federal Regulations (CFR) Part 212 for clinical use, or under the United States Pharmacopeia Chapter <823> for clinical research. It is fully equipped with 19 Becquerel Sievert (BqSv) hot cells, 2 dispensing hot cells and a Laminar Flow Hotcell. The GMP facility is licensed as an FDA Manufacturer for the production of Abbreviated New Drugs (ANDAs), FDG and N-13 Ammonia, and is licensed as WUSTL PET Nuclear Pharmacy under the State of Missouri Board of Pharmacy. The RPL has 4 BqSv hot cells for target processing. It has a special configuration including a double stack hot cell (DSC-100), large dispensing hot cell with tongs (LDHT-100) and an a large single hot cell (LSHC-100) enabling the automatic processing and dispensing of Cu-64, Zr-89, Br-76, Br-77 and other isotopes. The processing automation was developed at Washington University with the dispensing system being developed by BqSv according to Washington University’s specifications.
Service available to All entities, including for-profit organizations.
Priority service for Specific groups, centers or departments – see Additional Information for details.
Only authorized individuals are allowed access to the cyclotron facility.
- The MIR Cyclotron Facility mission is to provide PET isotopes, radiochemicals, radio-tracers and radiopharmaceuticals to the research and medical community for use in research and clinical practice, meeting or exceeding user requirements, while safely and reliably insuring the highest level of quality reasonably achievable, following federal regulations and guidelines.
- 3 cyclotrons: TR-19/9, CTI RDS111 cyclotron, Japan Steel Works 16/8
- 41 shielded workspaces
- 6 laminar flow hot cell
- a general chemistry hot cell with manipulator arms
- 6 gas chromatographs
- 8 HPLC systems
- 2 IC systems
- other equipment (i.e., automated chemistry systems) necessary for the production of PET radiopharmaceuticals
Pricing is subject to core verification
Contact J.P LaVenture at firstname.lastname@example.org or Greg Gaehle at email@example.com for current pricing information.
Center for Clinical Imaging Research (CCIR)
Institute of Clinical and Translational Sciences (ICTS)
Small Animal Imaging Facility
Clinical PET Imaging