The Mission of the Mouse Genetics Core (MGC) is to provide a cost-effective method for generating and maintaining genetically altered mice for the entire Washington University research community.

Core Description

The MGC is a Core facility that provides a variety of technical procedures for scientists that use the mouse as an experimental model.  The MGC offers many technical services including generation of transgenic mice from DNA constructs provided by the investigators, generation of knockout, knock-in, conditional, and point mutations in mice using the CRISPR/Cas9 system for mutagenesis and genome editing, animal husbandry, genotyping by PCR, embryo, oocyte, and sperm cryopreservation and recovery for storage of mouse lines, in vitro fertilization and embryo transfer for rederivation and assisted reproductive purposes.  The MGC also offers ovarian transplants, vasectomies, congenic genotyping for testing strain contribution, and drug administration or tissue biopsies for further study by investigators.

Access

Service available to All entities, including for-profit organizations.

Priority service for Washington University only.

Services

  • Production of CRISPR/Cas9 mediated mutant mice, Production of Transgenic Mice
  • Genotyping by PCR
  • Animal Husbandry
  • Sperm Cryopreservation
  • Oocyte Cryopreservation
  • Embryo Cryopreservation
  • Speed Congenics
  • In Vitro Fertilization
  • Rederivations
  • Ovarian Transplants
  • Vasectomies
  • Tissue Biopsy
  • Drug administration, Microsurgery
  • Many other services available, please inquire

Equipment

  • Inverted Microscopes
  • Dissecting Microscopes
  • XY Zyclone Laser
  • Piezo Drill
  • Multiple PCR Machines
  • Electrophoresis Equipment
  • Liquid Nitrogen Storage Tanks
  • Cryopreservation equipment

Pricing

Pricing is subject to core verification

Please see our Website for current pricing.  Information on pricing for Center Members is available at each of their websites.   http://mgc.wustl.edu/​


AFFILIATIONS
Children’s Discovery Institute
Diabetes Research and Training Center (DRTC)
Digestive Disease Research Core Center (DDRCC)
Department of Neuroscience
Department of Neurology
Department of Medicine
Department of Developmental Biology
Department of Pediatrics
Diabetes Research Center (DRC)
Washington University Musculoskeletal Research Center (MRC)