Animal models (including transgenic and knock-out mouse models) are routinely used to identify biomarkers of human diseases and to devise novel therapeutic strategies. In vivo, non-invasive imaging of mice and rats is ideally suited to assess the efficacy of such biomarkers, characterize mechanisms of disease progression, and assess response to therapy longitudinally in preclinical rodent […]
The Animal Model Research Core provides breeding and colony maintenance of rodent models used for nutrition-related research (e.g., animals with lipid abnormalities, atherosclerosis, obesity and diabetes), genotyping, histological analyses, biochemical measurements (plasma lipids, glucose, and hormones) and body composition analyses.
The Cellular and Molecular Biology Core (CMBC) is specifically tailored to meet the needs of Nutrition Obesity Research Center (NORC) investigators in basic and clinical departments who wish to conduct nutrition- or obesity- related molecular research. The CMBC provides support for the study of adipose tissue biology and of the molecular basis of nutritional effects […]